WebMar 1, 2024 · Indeed, RSL3 and other small-molecule GPX4 inhibitors can induce ferroptosis in not only cultured cancer cells but also tumor xenografts implanted in mice. Similarly, erastin and other system Xc− inhibitors can deplete intracellular glutathione required for GPX4 function, leading to lipid peroxidation and ferroptosis. WebMar 15, 2024 · Ferroptosis was recognized as a distinct mechanism of nonapoptotic programmed cell death through a small-molecule screen, and erastin and RSL3 were identified as compounds that induce selective lethality in cancer cells that express mutant HRAS (24, 35–38).
O-GlcNAcylation enhances sensitivity to RSL3-induced …
WebApr 14, 2024 · Ferroptosis, a novel programmed cell death, is closely related to tumor development. In this research, we aimed to explore the role and mechanism of BCL6 in malignant progression and ferroptosis of gastric cancer. ... First of all, we found that the overexpressed BCL6 increased ferroptosis inducer RSL3- or erastin-induced cell death, … WebOct 30, 2024 · We found that ferroptosis inducer RSL3 inhibited lipopolysaccharides (LPS)-induced inflammation of microglia and peritoneal macrophages (PMs) in a cell ferroptosis-independent manner, whereas cell ferroptosis-conditioned medium significantly triggered inflammation of microglia and PMs. home theater concrete walls
Targeting prominin2 transcription to overcome ferroptosis resistance …
WebMar 17, 2024 · Tubastatin A induced ferroptosis by directly interacting with and inhibiting the enzymatic activity of GPX4 in cancer cells, which is independent of HDAC6 inhibition. … WebMar 15, 2024 · The small molecules RSL3 and ML162 induce ferroptosis by inhibiting GPX4 function, which is blocked by the cooperation of GPX4 and vitamin E [25, 26]. Like RSL3, EC330/EC359 inhibit the activity of GPX in cells, but unlike RSL3, they reduce the level of GSH in cells [ 27 ]. iPLA2β acts as a major ferroptosis repressor to mediate detoxification ... WebJun 1, 2024 · Herein, RSL3@PCA was designed to simultaneously deplete intracellular GSH and inhibit the activity of GPX4, thereby significantly promoting tumor cell ferroptosis. RSL3@PCA was successfully prepared by encapsulating a selective inhibitor of GPX4 into acid-responsive nanoparticle PCA. his eldest son