WebFeb 3, 2016 · Each study included very low numbers of patients with “poor” renal function (range 6-18 patients each). There was no standardized definition of “poor” renal function, and Scr values were oftentimes missing. Many patients would have met the definition of “end stage renal disease” and should not have received the medication. In pharmacology, clearance is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time. Usually, clearance is measured in L/h or mL/min. The quantity reflects the rate of drug elimination divided by plasma concentration. Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and excretion of a substance are …

New Horizons in Predictive Drug Metabolism and Pharmacokinetics

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Opioid Use in Renal Failure - Palliative Care Network of Wisconsin

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