WebMar 29, 2024 · Reviewed on 3/29/2024. Cisplatin: An anticancer drug that belongs to the family of drugs called platinum compounds. Cisplatin is used in the treatment of a wide … WebCisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to bind to a guanine base on DNA. This property is …
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WebOwing to its ASNS targeting ability, complex 2-33 exhibited similar in vitro anti-tumor activity and less in vivo side toxicity relative to cisplatin by limiting the availability of asparagine. 76 ... Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side … See more Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some See more Cisplatin is the square planar coordination complex cis-[Pt(NH3)2Cl2]. The prefix cis indicates the cis isomer in which two similar ligands are in adjacent positions. The systematic … See more Syntheses of cisplatin start from potassium tetrachloroplatinate. Several procedures are available. One obstacle is the facile formation of Magnus's green salt (MGS), which has the same empirical formula as cisplatin. The traditional way to avoid MGS involves the … See more Cisplatin has a number of side effects that can limit its use: • Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical … See more Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water … See more The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's … See more Cisplatin has been studied with Auger therapy to increase the therapeutic effects of cisplatin, without increasing normal tissue toxicities. See more
WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, … WebSep 12, 2024 · The platinum coordination complexes are a group of antineoplastic agents that are usually classified as alkylating agents, but which have distinctive features. Their anticancer activity appears to relate to the cross linking of DNA molecules in a fashion similar to standard alkylating agents.
WebMontgomery County, Kansas. Date Established: February 26, 1867. Date Organized: Location: County Seat: Independence. Origin of Name: In honor of Gen. Richard Montgomery (1738-1775), a Revolutionary War hero who led the army into Canada, capturing the city of Montreal; he died while attempting to capture Quebec. WebFeb 28, 2024 · It was discovered that both iodide complexes, 9a and 9b, were more effective than the chloride analogs, 10a and 10b, and cisplatin against all cisplatin-resistant cell lines; while the chloride complexes had an effect comparable to cisplatin: 11 and 11.9 μM vs. 4 μM in the A2780 cell line; 21 and 19 μM vs. 22 μM in the A2780cisR …
WebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity …
WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation. flipkart order tracking with order idWebMay 10, 2024 · Notable examples include the anticancer drugs cisplatin ( PtCl 2 ( NH 3) 2 ). A square planar complex also has a coordination number of 4. The structure of the complex differs from tetrahedral because the ligands form a simple square on the x and y axes. Because of this, the crystal field splitting is also different (Figure 1 ). flipkart otp issueWebJul 19, 2024 · Cisplatin and drug design 16–18 years Resource RSC Education Assess learners’ understanding of the mechanism of cisplatin as an anticancer drug with these examination-style questions. flipkart out of stock for pincodegreatest diamondbacks of all timeWebMar 20, 2024 · Till today, cisplatin, carboplatin, and oxaliplatin are still extensively applied in the treatment of cancer. Cisplatin ( Figure 1) is a neutral, square planar coordination complex of platinum (II) coordinated to two chloride and two ammonia groups, where the chloride ligands are in the cis-geometry ( Kartalou and Essigmann, 2001 ). greatest detroit red wings playersWebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of … greatest disasters in human historyWeb2 hours ago · Pivovarova and colleagues designed and evaluated copper coordination compounds containing thiazole-based derivatives. In the proposed series, two copper complexes exhibited cytotoxic effects on breast cancer cells with selectivity towards tumourigenic cells over healthy ones, definitively proving the efficacy of the proposed … greatest director of all time