Cisplatin and kidney damage
Webwww.ncbi.nlm.nih.gov WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms …
Cisplatin and kidney damage
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WebCisplatin and kidney damage Kent Cass Member Posts: 1,898 Member January 2010 edited March 2014 #1 The subject of kidney damage as a result of chemo by Cisplatin … WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause...
WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …
WebMar 29, 2024 · In cisplatin-treated wildtype mice, there were increases in biomarkers of CIAKI, in addition to histological indication of kidney damage such as tubule dilation and … WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe …
WebApr 12, 2024 · In the end, the kidney is heavily involved in the elimination of the drugs, and, as a consequence, kidney damage can lead to an altered excretion of the drugs and …
WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has … small world financial services spain s.aWebTubular epithelial cells (TECs) is one of the most damaged cells in cisplatin induced AKI ( Xu et al., 2015 ). The well-known mechanism by which cisplatin exerts its anticancer effects—DNA damage—also affecting renal cells ( Tchounwou et al., 2024 ). hilary achauerWebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. hilary ackermanWebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for patients with eGFR from 50 to 59.9 mL/min may result in a higher cumulative dose of cisplatin without higher renal toxicity, whic … small world financial services group ltdWebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ]. hilary adams atlanta attorneyWebNov 24, 2024 · bloating or swelling of the face, arms, hands, lower legs, or feet blood in the urine or stools blurred vision burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain chills cloudy urine confusion cough coughing up blood diarrhea difficult or labored breathing difficulty in moving hilary acklandWebing on pathologic examination of human kidneys affected by cisplatin toxicity. Both proximal and distaltubulesareaffected,andinpatientswithAKI, there is usually acute tubular necrosis. Long-term cisplatin exposure may also cause cyst formation and interstitial fibrosis (Figure 1) (3). Patients with cisplatin toxicity typically present small world financial services sweden ab