WebMar 22, 2024 · Elimination. Organ-independent Hofmann elimination (a chemical process dependent on pH and temperature) is the predominant pathway for the elimination of … WebAtracurium is a new neuromuscular blocking agent which has an unique mode of elimination by spontaneous degradation in slightly alkali solution, according to the Hofmann elimination. The Hofmann elimination is completed in plasma (in vitro or in vivo) by an ester hydrolysis. The major degradation product is laudanosine.
Laudanosine - an overview ScienceDirect Topics
WebFeb 1, 2024 · Elimination. Organ-independent Hofmann elimination (a chemical process dependent on pH and temperature) is the predominant pathway for the elimination of … WebHofmann elimination is a spontaneous, base-catalyzed, nonenzymatic chemical reaction by which atracurium is cleaved into two molecules. 125,129 Alkalosis increases resistance to atracurium-induced neuromuscular block, 130 while hypothermia slows the temperature-dependent breakdown so that less atracurium is required to maintain a given depth of … software needed for networking
Cisatracurium dosing in a patient with hyperthermia
WebPlasma cisatracurium and metabolite concentration data collected in healthy adult patients receiving 0.1 or 0.2 mg *symbol* kg sup -1 doses of cisatracurium are consistent with data from in vitro experiments that suggest that Hofmann elimination is an important pathway for the elimination of cisatracurium. WebClinical use of neuromuscular blocking agents in anesthesia. …intubating dose of cisatracurium, the clinical duration of action is 35 to 50 minutes. Pharmacokinetics – Cisatracurium is also primarily metabolized through Hofmann elimination. Cisatracurium has no active …. Neuromuscular blocking agents in critically ill patients: Use, agent ... WebCisatracurium and atracurium are short-acting because they undergo spontaneous decomposition under physiologic conditions. We have all heard of the process termed a … slow is fast fast is smooth quote